Pure and Applied Chemistry, 2003, Volume 75, No. 11-12

Nuclear receptor superfamily: Principles of signaling

Pierre Germain, Lucia Altucci, William Bourguet, C. Rochette-Egly and Hinrich Gronemeyer

p. 1619 [Details + Abstract] [Full text - pdf 3644 kB]

Nuclear receptor coregulators

N. J. McKenna and B. W. O'Malley

p. 1665 [Details + Abstract] [Full text - pdf 163 kB]

Function and mode of action of nuclear receptors: Estrogen, progesterone, and vitamin D

E. A. Kimbrel and D. P. McDonnell

p. 1671 [Details + Abstract] [Full text - pdf 273 kB]

Biological function and mode of action of the androgen receptor

E. M. Wilson

p. 1685 [Details + Abstract] [Full text - pdf 177 kB]

Genetic dissection of gluco- and mineralocorticoid receptor function in mice

E. F. Greiner, S. Berger and G. Schütz

p. 1699 [Details + Abstract] [Full text - pdf 243 kB]

Functions of RARs and RXRs in vivo: Genetic dissection of the retinoid signaling pathway

Manuel Mark and Pierre Chambon

p. 1709 [Details + Abstract] [Full text - pdf 264 kB]

Biological function and mode of action of nuclear xenobiotic receptors

J. Sonoda and R. M. Evans

p. 1733 [Details + Abstract] [Full text - pdf 213 kB]

Molecular mechanisms of cross-talk between growth factors and nuclear receptor signaling

D. Picard

p. 1743 [Details + Abstract] [Full text - pdf 217 kB]

Estrogen receptor action through target genes with classical and alternative response elements

P. J. Kushner, P. Webb, R. M. Uht, M.-M. Liu and R. H. Price, Jr.

p. 1757 [Details + Abstract] [Full text - pdf 465 kB]

Nuclear receptor action involved with sex differentiation

I. A. Hughes, Howard Martin, Jarmo Jääskeläinen and C. L. Acerini

p. 1771 [Details + Abstract] [Full text - pdf 328 kB]

Human disorders caused by nuclear receptor gene mutations

J. C. Achermann and J. L. Jameson

p. 1785 [Details + Abstract] [Full text - pdf 293 kB]

Interactions of exogenous endocrine active substances with nuclear receptors

J. A. Katzenellenbogen and R. Muthyala

p. 1797 [Details + Abstract] [Full text - pdf 376 kB]

Transcriptional roles of AhR in expression of biological effects induced by endocrine disruptors

Yoshiaki Fujii-Kuriyama and J. Mimura

p. 1819 [Details + Abstract] [Full text - pdf 199 kB]

Nonmammalian nuclear receptors: Evolution and endocrine disruption

J. W. Thornton

p. 1827 [Details + Abstract] [Full text - pdf 210 kB]

Analysis of endocrine active substances in food and the environment

P. T. Holland

p. 1843 [Details + Abstract] [Full text - pdf 209 kB]

Naturally produced steroid hormones and their release into the environment

L. S. Shore and M. Shemesh

p. 1859 [Details + Abstract] [Full text - pdf 172 kB]

Concentration of phytohormones in food and feed and their impact on the human exposure

Ph. Verger and J. C. LeBlanc

p. 1873 [Details + Abstract] [Full text - pdf 159 kB]

Pharmaceuticals and personal care products - A source of endocrine disruption in the environment?

F. Ingerslev, E. Vaclavik and B. Halling-Sørensen

p. 1881 [Details + Abstract] [Full text - pdf 223 kB]

Endocrine active industrial chemicals: Release and occurrence in the environment

A. Johnson and M. Jürgens

p. 1895 [Details + Abstract] [Full text - pdf 165 kB]

Release of pesticides into the environment and initial concentrations in soil, water, and plants

K. D. Racke

p. 1905 [Details + Abstract] [Full text - pdf 171 kB]

Role of metabolism in the endocrine-disrupting effects of chemicals in aquatic and terrestrial systems

M. van den Berg, T. Sanderson, N. Kurihara and A. Katayama

p. 1917 [Details + Abstract] [Full text - pdf 310 kB]

Critical factors in exposure modeling of endocrine active substances

P. de Voogt and B. van Hattum

p. 1933 [Details + Abstract] [Full text - pdf 244 kB]

Environmental fate and metabolism: Issues and recommendations

P. de Voogt, B. Halling-Sørensen, B. van Hattum, P. T. Holland, F. Ingerslev, A. Johnson, M. Jürgens, A. Katayama, W. Klein, N. Kurihara, J. C. Leblanc, K. D. Racke, T. Sanderson, M. Shemesh and L. S. Shore

p. 1949 [Details + Abstract] [Full text - pdf 138 kB]

Interactions of xenobiotics with the steroid hormone biosynthesis pathway

T. Sanderson and M. van den Berg

p. 1957 [Details + Abstract] [Full text - pdf 289 kB]

Organochlorine compounds and breast cancer risk

M. A. Mendez and Lenore Arab

p. 1973 [Details + Abstract] [Full text - pdf 270 kB]

Prevention of ambiguous genitalia by prenatal treatment with dexamethasone in pregnancies at risk for congenital adrenal hyperplasia

M. I. New

p. 2013 [Details + Abstract] [Full text - pdf 381 kB]

Male reproductive disorders and the role of endocrine disruption: Advances in understanding and identification of areas for future research

R. M. Sharpe and N. E. Skakkebaek

p. 2023 [Details + Abstract] [Full text - pdf 218 kB]

Brominated flame retardants and endocrine disruption

J. G. Vos, Georg Becher, M. van den Berg, J. de Boer and P. E. G. Leonards

p. 2039 [Details + Abstract] [Full text - pdf 213 kB]

Toxicity vs. beneficial effects of phytoestrogens

H. Wanibuchi, J. S. Kang, E. I. Salim, K. Morimura and S. Fukushima

p. 2047 [Details + Abstract] [Full text - pdf 150 kB]

Evaluation of thyroid function in neonatal and adult rats: The neglected endocrine mode of action

M. S. Christian and N. A. Trenton

p. 2055 [Details + Abstract] [Full text - pdf 230 kB]

Modification of endocrine active potential by mixtures

Kevin Gaido, Li You and S. Safe

p. 2069 [Details + Abstract] [Full text - pdf 241 kB]

Experience with new testing guidelines with endocrine-sensitive end-points

R. W. Tyl

p. 2081 [Details + Abstract] [Full text - pdf 385 kB]

Critical evaluation of observed adverse effects of endocrine active substances on reproduction and development, the immune system, and the nervous system

J. C. O'Connor and R. E. Chapin

p. 2099 [Details + Abstract] [Full text - pdf 295 kB]

Significance of experimental studies for assessing adverse effects of endocrine-disrupting chemicals

L. E. Gray, Jr. and P. M. D. Foster

p. 2125 [Details + Abstract] [Full text - pdf 359 kB]

Determination of acceptable exposure levels for humans for endocrine active substances: Use of animal models

P. A. Fenner-Crisp

p. 2143 [Details + Abstract] [Full text - pdf 148 kB]

Use of NOAEL, benchmark dose, and other models for human risk assessment of hormonally active substances

R. W. Setzer, Jr. and C. A. Kimmel

p. 2151 [Details + Abstract] [Full text - pdf 159 kB]

Endocrine active substances and dose response for individuals and populations

H. A. Barton

p. 2159 [Details + Abstract] [Full text - pdf 166 kB]

Endocrine disruption occurring at doses lower than those predicted by classical chemical toxicity evaluations: The case bisphenol A

J. Ashby

p. 2167 [Details + Abstract] [Full text - pdf 285 kB]

Environmental estrogens and sperm counts

Harry Fisch and Robert Golden

p. 2181 [Details + Abstract] [Full text - pdf 176 kB]

Historical perspective on endocrine disruption in wildlife

P. Matthiessen

p. 2197 [Details + Abstract] [Full text - pdf 172 kB]

Endocrine disruption in invertebrates

J. Oehlmann and U. Schulte-Oehlmann

p. 2207 [Details + Abstract] [Full text - pdf 394 kB]

Endocrine disruption in wild freshwater fish

S. Jobling and C. R. Tyler

p. 2219 [Details + Abstract] [Full text - pdf 372 kB]

Effects of endocrine disruptors in aquatic mammals

M. C. Fossi and Letizia Marsili

p. 2235 [Details + Abstract] [Full text - pdf 410 kB]

Endocrine disruption in marine fish

P. Matthiessen

p. 2249 [Details + Abstract] [Full text - pdf 183 kB]

Deformed frogs and environmental retinoids

David Gardiner, A. Ndayibagira, Felix Grün and Bruce Blumberg

p. 2263 [Details + Abstract] [Full text - pdf 224 kB]

Contaminant-induced endocrine and reproductive alterations in reptiles

L. J. Guillette, Jr. and Taisen Iguchi

p. 2275 [Details + Abstract] [Full text - pdf 343 kB]

Review of the effects of endocrine-disrupting chemicals in birds

J. P. Giesy, L. A. Feyk, P. D. Jones, Kurunthachalam Kannan and T. Sanderson

p. 2287 [Details + Abstract] [Full text - pdf 199 kB]

Wildlife as models for the study of how mixtures, low doses, and the embryonic environment modulate the action of endocrine-disrupting chemicals

David Crews, O. Putz, P. Thomas, Tyrone Hayes and Kembra Howdeshell

p. 2305 [Details + Abstract] [Full text - pdf 192 kB]

Interactions of endocrine-disrupting chemicals with stress responses in wildlife

T. G. Pottinger

p. 2321 [Details + Abstract] [Full text - pdf 179 kB]

Effects of endocrine active substances in wildlife species: Genetic, biochemical, and physiological factors in variable susceptibility to endocrine disruptors

Shin'ichiro Kawai, M. Kobayashi and Hideo Kaneko

p. 2335 [Details + Abstract] [Full text - pdf 232 kB]

Development of fish tests for endocrine disruptors

T. H. Hutchinson, H. Yokota, S. Hagino and K. Ozato

p. 2343 [Details + Abstract] [Full text - pdf 304 kB]

Endocrine disruption in wildlife: The future?

J. P. Sumpter

p. 2355 [Details + Abstract] [Full text - pdf 128 kB]

Mechanism-based QSAR approach to the study of the toxicity of endocrine active substances

C. D. Selassie, R. Garg and S. Mekapati

p. 2363 [Details + Abstract] [Full text - pdf 230 kB]

Regulatory application of SAR/QSAR for priority setting of endocrine disruptors: A perspective

W. Tong, Hong Fang, H. Hong, Q. Xie, R. Perkins, Jeanne Anson and D. M. Sheehan

p. 2375 [Details + Abstract] [Full text - pdf 527 kB]

QSAR prioritization of chemical inventories for endocrine disruptor testing

P. Schmieder, Ovanes Mekenyan, Steven Bradbury and G. Veith

p. 2389 [Details + Abstract] [Full text - pdf 185 kB]

The nature of the ligand-binding pocket of estrogen receptor alpha and beta: The search for subtype-selective ligands and implications for the prediction of estrogenic activity

J. A. Katzenellenbogen, R. Muthyala and B. S. Katzenellenbogen

p. 2397 [Details + Abstract] [Full text - pdf 412 kB]

Fragment molecular orbital study of the binding energy of ligands to the estrogen receptor

Kaori Fukuzawa, Kazuo Kitaura, K. Nakata, Tsuguchika Kaminuma and T. Nakano

p. 2405 [Details + Abstract] [Full text - pdf 240 kB]

Toxicogenomics: Impact on human health

J. K. Selkirk

p. 2413 [Details + Abstract] [Full text - pdf 108 kB]

Temporal responses to estrogen in the uterus

K. C. Fertuck and T. R. Zacharewski

p. 2415 [Details + Abstract] [Full text - pdf 135 kB]

Application of toxicogenomics to the endocrine disruption issue

T. Shirai and Makoto Asamoto

p. 2419 [Details + Abstract] [Full text - pdf 144 kB]

Transcript profiles elicited by developmental exposure to endocrine-mediated toxicants

George P. Daston

p. 2423 [Details + Abstract] [Full text - pdf 140 kB]

Use of gene expression profiling to understand the transcriptional program associated with estrogen-induced uterine growth

J. G. Moggs, D. G. Deavall and G. Orphanides

p. 2429 [Details + Abstract] [Full text - pdf 136 kB]

Need for establishing integrated programs to monitor endocrine active compounds

H. Segner

p. 2435 [Details + Abstract] [Full text - pdf 166 kB]

Search for the evidence of endocrine disruption in the aquatic environment; Lessons to be learned from joint biological and chemical monitoring in the European project COMPREHEND

R. I. L. Eggen, B.-E. Bengtsson, C. T. Bowmer, A. A. M. Gerritsen, Michel Gibert, Kjetil Hylland, A. C. Johnson, Pim Leonards, T. Nakari, L. Norrgren, J. P. Sumpter, M. J.-F. Suter, A. Svenson and A. D. Pickering

p. 2445 [Details + Abstract] [Full text - pdf 145 kB]

Biomonitoring: Integration of biological end-points into chemical monitoring

M. Seifert, L. Wen, M. Alberti, U. Kausch and B. Hock

p. 2451 [Details + Abstract] [Full text - pdf 486 kB]

Identifying the causative agents: The use of combined chemical and biological strategies in monitoring programs

E. J. Routledge

p. 2461 [Details + Abstract] [Full text - pdf 141 kB]

Closing the gap between exposure and effects in monitoring studies

D. E. Tillitt and D. M. Papoulias

p. 2467 [Details + Abstract] [Full text - pdf 158 kB]

Simple, rapid assays for conventional definite testing of endocrine disruptor hazard: Summary and recommendations

S. Fukushima and A. Freyberger

p. 2479 [Details + Abstract] [Full text - pdf 117 kB]

Testing of endocrine active substances using an enhanced OECD test guideline 407: Experiences from studies on flutamide and ethinylestradiol

A. Freyberger, Peter Andrews, Elke Hartmann, Rolf Eiben, Ingo Loof, U. Schmidt, M. Temerowski, Andree Folkerts, Michael Becka, B. Stahl and Martin Kayser

p. 2483 [Details + Abstract] [Full text - pdf 143 kB]

Application of rat medium-term bioassays for detecting carcinogenic and modifying potentials of endocrine active substances

Katsumi Imaida, S. Tamano, Akihiro Hagiwara, S. Fukushima, T. Shirai and Nobuyuki Ito

p. 2491 [Details + Abstract] [Full text - pdf 181 kB]

Enhanced one-generation reproductive toxicity study in rats for detecting endocrine-disrupting effects of chemicals

H. Aoyama and K. Suzuki

p. 2497 [Details + Abstract] [Full text - pdf 152 kB]

Making decisions in the 21st century: Scientific data, weight of evidence, and the precautionary principle

J. Burger

p. 2505 [Details + Abstract] [Full text - pdf 171 kB]

Precautionary principle and endocrine active substances

B. D. Goldstein

p. 2515 [Details + Abstract] [Full text - pdf 122 kB]

Why epidemiology of endocrine disruptors warrants the precautionary principle

Michael Gochfeld

p. 2521 [Details + Abstract] [Full text - pdf 138 kB]

General process for the risk assessment of pesticides that interact with or affect the endocrine system

Karen Hamernik

p. 2531 [Details + Abstract] [Full text - pdf 116 kB]

Role of the precautionary principle in the EU risk assessment process on industrial chemicals

J. de Bruijn, Bjorn Hansen and S. Munn

p. 2535 [Details + Abstract] [Full text - pdf 125 kB]

Differing perspectives on the use of scientific evidence and the precautionary principle

J. Burger

p. 2543 [Details + Abstract] [Full text - pdf 112 kB]

Risk management options for endocrine disruptors in national and international programs

J. C. Lamb, IV, H. B. W. M. Koëter, R. Becker, A. Gies, Les Davies, T. Inoue, A. Jacobs, G. Lyons, M. Matsumoto and G. Timm

p. 2549 [Details + Abstract] [Full text - pdf 136 kB]

Hormonally active agents and plausible relationships to adverse effects on human health

T. Inoue

p. 2555 [Details + Abstract] [Full text - pdf 126 kB]

Government view of endocrine disruption in wildlife

A. Gies

p. 2563 [Details + Abstract] [Full text - pdf 152 kB]

Risk perception: A chemical industry view of endocrine disruption in wildlife

S. Webb, R. Taalman, R. Becker, K. Onuma and Koichi Igarashi

p. 2575 [Details + Abstract] [Full text - pdf 188 kB]

Endocrine active substances and the need to improve environmental protection: An environmentalist's perspective

G. Lyons

p. 2593 [Details + Abstract] [Full text - pdf 156 kB]

Endocrine disruption and the USFDA's Center for Drug Evaluation and Research

A. Jacobs, Paul Brown, James Farrelly, J. E. Fisher and D. Morse

p. 2605 [Details + Abstract] [Full text - pdf 128 kB]

Relevant activities for risk management of endocrine disruptors in Japanese government agencies

S. Oikawa and M. Matsumoto

p. 2609 [Details + Abstract] [Full text - pdf 111 kB]

Advancing the testing and assessment of chemical substances for endocrine disruption: OECD activities

H. B. W. M. Koëter

p. 2613 [Details + Abstract] [Full text - pdf 109 kB]

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2003, Vol. 75, Issue 11-12
Special Topic Issue on the Implications of Endocrine Active Substances for Humans and Wildlife