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Pure Appl. Chem., 2003, Vol. 75, No. 11-12, pp. 2429-2432

Use of gene expression profiling to understand the transcriptional program associated with estrogen-induced uterine growth

J. G. Moggs, D. G. Deavall and G. Orphanides

Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, SK10 4TJ, UK

Abstract: The use of gene expression data in predictive and mechanistic toxicology is hindered by a lack of information on the relationships between transcriptional events and physiological and pathological changes. We discuss the analysis of these relationships using the rodent uterotrophic response as a model experimental system for estrogen-induced uterine growth.