Cycloruthenated compounds as efficient catalyst for asymmetric hydride transfer reaction

Sortais, Jean-Baptiste; Barloy, Laurent; Sirlin, Claude; de Vries, André H. M.; de Vries, Johannes G.; Pfeffer, Michel

doi:10.1351/pac200678020457

Pure Appl. Chem., 2006, Vol. 78, No. 2, pp. 457-462

http://dx.doi.org/10.1351/pac200678020457

Cycloruthenated compounds as efficient catalyst for asymmetric hydride transfer reaction

Jean-Baptiste Sortais¹, Laurent Barloy¹, Claude Sirlin¹, André H. M. de Vries², Johannes G. de Vries² and Michel Pfeffer¹

¹ CNRS, UMR 7177, Laboratoire de Synthèses Métallo-Induites, Université Louis Pasteur, 4, rue Blaise Pascal, 67000 Strasbourg, France
² DSM Pharmaceutical Chemicals, Advanced Synthesis, Catalysis, and Development, P.O. Box 18, 6160 MD Geleen, The Netherlands

Abstract: Cycloruthenated complexes obtained by direct C-H activation of enantiopure aromatic primary and secondary amines are efficient catalysts in asymmetric hydride transfer reaction. Reduction of acetophenone has been achieved rapidly with enantiomeric excesses (ee's) ranging from 38 to 89 %. The importance of Ru-C bond in the catalytic efficiency is highlighted.