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Pure Appl. Chem., 2006, Vol. 78, No. 2, pp. 457-462

Cycloruthenated compounds as efficient catalyst for asymmetric hydride transfer reaction

Jean-Baptiste Sortais1, Laurent Barloy1, Claude Sirlin1, André H. M. de Vries2, Johannes G. de Vries2 and Michel Pfeffer1

1 CNRS, UMR 7177, Laboratoire de Synthèses Métallo-Induites, Université Louis Pasteur, 4, rue Blaise Pascal, 67000 Strasbourg, France
2 DSM Pharmaceutical Chemicals, Advanced Synthesis, Catalysis, and Development, P.O. Box 18, 6160 MD Geleen, The Netherlands

Abstract: Cycloruthenated complexes obtained by direct C-H activation of enantiopure aromatic primary and secondary amines are efficient catalysts in asymmetric hydride transfer reaction. Reduction of acetophenone has been achieved rapidly with enantiomeric excesses (ee's) ranging from 38 to 89 %. The importance of Ru-C bond in the catalytic efficiency is highlighted.