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Pure Appl. Chem., 2012, Vol. 84, No. 3, pp. 803-816

Published online 2012-02-15

Environmentally friendly approaches to the synthesis of new antibiotics from sugars*

Nuno M. Xavier and Amélia P. Rauter*

Faculdade de Ciências, Centro de Química e Bioquímica/Departamento de Química e Bioquímica, Universidade de Lisboa, Campo Grande, Ed. C8, Piso 5, 1749-016 Lisboa, Portugal

Abstract: In light of the biological importance of carbohydrates and their role when present in antibiotic agents, the design and synthesis of carbohydrate-based antibiotics has occupied a prominent place in drug discovery. This review focuses on synthetic carbohydrate antimicrobial agents, giving special emphasis to novel structures easily accessible from readily available carbohydrate precursors.
*Pure Appl. Chem. 84, 411–860 (2012). A collection of invited papers for the IUPAC project 2008-016-1-300 “Chlorine-free Synthesis for Green Chemistry”.