Pure Appl. Chem., 2012, Vol. 84, No. 3, pp. 803-816
http://dx.doi.org/10.1351/PAC-CON-11-11-11
Published online 2012-02-15
Environmentally friendly approaches to the synthesis of new antibiotics from sugars*
Abstract:
In light of the biological importance of carbohydrates and their role when present in antibiotic agents, the design and synthesis of carbohydrate-based antibiotics has occupied a prominent place in drug discovery. This review focuses on synthetic carbohydrate antimicrobial agents, giving special emphasis to novel structures easily accessible from readily available carbohydrate precursors.
*Pure Appl. Chem. 84, 411–860 (2012). A collection of invited papers for the IUPAC project 2008-016-1-300 “Chlorine-free Synthesis for Green Chemistry”.
Keywords
antibiotics; antimicrobial; carbohydrates; chemical synthesis; enzyme catalysis.