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Pure Appl. Chem., 2012, Vol. 84, No. 1, pp. 1-10

Published online 2011-12-08

The I2/Et3SiH system: A versatile combination with multiple applications in carbohydrate chemistry

Matteo Adinolfi, Alfonso Iadonisi*, Antonello Pastore and Silvia Valerio

Department of Organic Chemistry and Biochemistry, University of Naples “Federico II”, Via Cinthia 4, I-80126, Naples, Italy

Abstract: In this contribution, a brief survey of the multiple synthetic opportunities offered by the I2/Et3SiH combined system is presented. Both reagents are cheap and easy to handle, and their combination allows HI to be quickly formed in situ. A suitable stoichiometry of the mixture can be addressed to a set of very useful transformations of carbohydrate chemistry ranging from glycosidation reactions to functional group manipulation of sugars.