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Pure Appl. Chem., 2011, Vol. 83, No. 9, pp. 1709-1719

Published online 2011-03-29

Increased understanding of platinum anticancer chemistry

Jan Reedijk1,2

1 Department of Chemistry, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
2 Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands

Abstract: The development of a few worldwide routinely used Pt(II) coordination compounds is described from a mechanistic point of view and related to the molecular aspects of Pt-DNA binding. Mechanistic knowledge developed from these studies is applied nowadays for the design and synthesis of new bifunctional and trifunctional compounds, aimed for use as improved anticancer drugs.