Efficient and green synthesis of new polycyclic procyanidin derivatives via tandem dinucleophilic addition of indolin-2-thiones to flavylium salts

Moghaddam, Firouz Matloubi; Foroushani, Behzad Koushki; Saeidian, Hamdollah; Nourian, Saghar; Mirjafary, Zohreh; Kiamehr, Mostafa

doi:10.1351/PAC-CON-10-09-29

Pure Appl. Chem., 2011, Vol. 83, No. 3, pp. 709-713

http://dx.doi.org/10.1351/PAC-CON-10-09-29

Published online 2011-01-27

Efficient and green synthesis of new polycyclic procyanidin derivatives via tandem dinucleophilic addition of indolin-2-thiones to flavylium salts

Firouz Matloubi Moghaddam¹*, Behzad Koushki Foroushani¹, Hamdollah Saeidian^2,1, Saghar Nourian¹, Zohreh Mirjafary¹ and Mostafa Kiamehr¹

¹ Laboratory of Organic Synthesis and Natural Products, Department of Chemistry, Sharif University of Technology, P.O. Box 11155-9516, Tehran, Iran
² Department of Science, Payame Noor University (PNU), Zanjan, Iran

Abstract: The green synthesis of a new series of polycyclic procyanidin derivatives has been achieved in good yields by tandem dinucleophilic addition of indolin-2-thiones to flavylium salts. The procedure is efficient and simple, and the substrates are easily available.