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Pure Appl. Chem., 2011, Vol. 83, No. 3, pp. 715-722

Published online 2011-02-01

2-Hydroxypropyl derivatives of 1,2,3‑thiadiazole and 1,2,3-triazole: Synthesis and antifungal activity

Yury Morzherin1*, Polina E. Prokhorova1, Dmitry A. Musikhin1, Tatiana V. Glukhareva1 and Zhijin Fan2

1 Ural Federal University, 19, Mira str., Ekaterinburg, Russia
2 State Key Laboratory of Elemento-Organic Chemistry, Nankai University, 94 Weijin Road, Nankai, District, Tianjin 300071, China

Abstract: A series of novel 5-(2-hydroxypropyl)amino-1,2,3-thiadiazole and 5-(2-hydroxy-propyl)sulfanyl-1,2,3-triazole derivatives were designed and synthesized as candidate fungicides. The new compounds were identified by NMR and IR spectroscopy, mass spectrometry, and elemental analysis. Their antifungal activities were evaluated.