Pure Appl. Chem., 2011, Vol. 83, No. 3, pp. 597-605
http://dx.doi.org/10.1351/PAC-CON-10-09-03
Published online 2011-01-21
Enantioselective construction of new chiral cyclic scaffolds using [2 + 2 + 2] cycloaddition
Abstract:
Two types of enantioselective [2 + 2 + 2] cycloadditions of triynes using chiral rhodium catalysts are disclosed. The intramolecular reaction of ortho-aminophenol-tethered triynes provides chiral tripodal compounds. Consecutive inter- and intramolecular reactions of ortho-phenylene-tethered triynes provide chiral tetraphenylenes.
Keywords
asymmetric synthesis; cage compounds; chirality; cycloaddition; enantioselectivity; polyaryl compounds; rhodium; tetraphenylenes; triynes.