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Pure Appl. Chem., 2010, Vol. 82, No. 7, pp. 1429-1441

Published online 2010-05-04

Developing chiral phosphorus ligands for asymmetric hydrogenations

Wei Li, Guohua Hou, Xianfeng Sun, Gao Shang, Weicheng Zhang and Xumu Zhang*

Department of Chemistry and Chemical Biology and Department of Pharmaceutical Chemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA

Abstract: Chiral rigid and electron-donating phosphocyclic phosphine ligands and modular atropisomeric biaryl phosphine ligands were designed and synthesized. The performance of these chiral ligands in the asymmetric hydrogenations of prochiral dehydroamino acid derivatives, enamides, imines, keto esters, and ketones has been demonstrated to be excellent.