Pure Appl. Chem., 2008, Vol. 80, No. 4, pp. 727-742
http://dx.doi.org/10.1351/pac200880040727
Total synthesis of complex heterocyclic natural products
Abstract:
Total synthesis campaigns toward complex heterocyclic natural products are a prime source of inspiration for the design and execution of complex cascade sequences, powerful reactions, and efficient synthetic strategies. We highlight selected examples of such innovations in the course of our total syntheses of diazonamide A, azaspiracid-1, thiostrepton, 2,2'-epi-cytoskyrin A and rugulosin, abyssomycin C, platensimycin, and uncialamycin.
Keywords
antibiotics; antitumor agents; marine neurotoxins; natural products; total synthesis.