Pure Appl. Chem., 2008, Vol. 80, No. 4, pp. 743-749
http://dx.doi.org/10.1351/pac200880040743
Chiral phenyl-bis(oxazoline) as an efficient auxiliary for asymmetric catalysis
Abstract:
A new class of phenyl-bis(oxazoline) auxiliaries was readily prepared from isophthaloyl chloride and appropriate β-amino alcohols, and the derived rhodium complexes underwent new cyclization reactions at the metal center and exhibited high catalytic efficiency for asymmetric conjugate reduction of α,β-unsaturated carbonyl compounds and reductive aldol reactions of aldehydes and ketones.