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Pure Appl. Chem., 2008, Vol. 80, No. 11, pp. 2309-2326

Development of novel linear, block, and branched oligoelectrolytes and functionally targeting nanoparticles

Alexander Zaichenko1, Natalya Mitina1, Oleh Shevchuk1, Katerina Rayevska1, Volodymyr Lobaz1, Taras Skorokhoda1 and Rostyslav Stoika2

1 Lviv Polytechnic National University, 12 S. Bandera Str., Lviv, 79013, Ukraine
2 Institute of Cell Biology, National Academy of Sciences of Ukraine, Drahomanov Str., 14/16, 79005, Lviv, Ukraine

Abstract: The objective of the present study is development of novel surface-active block, comb-like, and branched copolymers with peroxide-containing chains, as well as derived functional luminescent and magnetic nanoparticles. The main experimental approaches are based on tailored synthesis of the oligoperoxide surfactants of desired structures and derived coordinating complexes of transitional and rare earth elements. Oligoperoxide-based synthesis of luminescent, magnetic, and other functional nanocomposites with controlled size distribution, functionality, reactivity, and biocompatibility is described. Developed methods provide combining the formation of polymeric, metal, and metal-oxide nanoparticles with irreversible modification of their surface by functional fragments capable of radical and other reactions, including binding of physiologically active substances. Novel nanoparticles were studied by chemical, colloidal-chemical, and rheological methods, X-ray diffraction technique, luminescent spectroscopy, and transmission and scanning electronic microscopy. The availability of ditertiary peroxide fragments on the nanoparticle surface provides a possibility of radical grafting functional polymer chains. The developed functional nanoparticles have been used for phagocytosis measurement, as well as markers of pathological cells, antimicrobial remedies, and nanocarriers for targeted drug delivery.