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Pure Appl. Chem., 2007, Vol. 79, No. 6, pp. 955-968

Chemical parameters influencing fine-tuning in the binding of macrolide antibiotics to the ribosomal tunnel

Erez Pyetan, David Baram, Tamar Auerbach-Nevo and Ada Yonath

Department of Structural Biology, the Weizmann Institute of Science, 76100 Rehovot, Israel

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  • Wilson Daniel N.: On the specificity of antibiotics targeting the large ribosomal subunit. Annals of the New York Academy of Sciences 2011, 1241, 1. <>
  • Kannan Krishna, Mankin Alexander S.: Macrolide antibiotics in the ribosome exit tunnel: species-specific binding and action. Annals of the New York Academy of Sciences 2011, 1241, 33. <>
  • Yonath Ada: Winterschlafende Bären, Antibiotika und die Evolution des Ribosoms (Nobel-Aufsatz). Angew Chem 2010, 122, 4438. <>
  • Yonath Ada: Hibernating Bears, Antibiotics, and the Evolving Ribosome (Nobel Lecture). Angew Chem Int Ed 2010, 49, 4340. <>
  • Przybylski Piotr, Pyta Krystian, Stefańska Joanna, Brzezinski Bogumil, Bartl Franz: Structure elucidation, complete NMR assignment and PM5 theoretical studies of new hydroxy-aminoalkyl-α,β-unsaturated derivatives of the macrolide antibiotic josamycin. Magn Reson Chem 2010, 48, 286. <>
  • DePaul A. J., Thompson E. J., Patel S. S., Haldeman K., Sorin E. J.: Equilibrium conformational dynamics in an RNA tetraloop from massively parallel molecular dynamics. Nucleic Acids Res 2010, 38, 4856. <>
  • David-Eden H., Mankin A. S., Mandel-Gutfreund Y.: Structural signatures of antibiotic binding sites on the ribosome. Nucleic Acids Res 2010, 38, 5982. <>
  • Zimmerman Ella, Yonath Ada: Biological Implications of the Ribosome's Stunning Stereochemistry. Chem Eur J of Chem Bio 2009, 10, 63. <>
  • Fulle Simone, Gohlke Holger: Molecular recognition of RNA: challenges for modelling interactions and plasticity. J Mol Recognit 2009, n/a. <>
  • Kondo Jiro, Westhof Eric: Base pairs and pseudo pairs observed in RNA-ligand complexes. J Mol Recognit 2009, n/a. <>
  • Wekselman Itai, Davidovich Chen, Agmon Ilana, Zimmerman Ella, Rozenberg Haim, Bashan Anat, Berisio Rita, Yonath Ada: Ribosome's mode of function: myths, facts and recent results. J Peptide Sci 2009, 15, 122. <>
  • Fulle Simone, Gohlke Holger: Statics of the Ribosomal Exit Tunnel: Implications for Cotranslational Peptide Folding, Elongation Regulation, and Antibiotics Binding. Journal of Molecular Biology 2009, 387, 502. <>
  • Sadeghi-Khomami Ali, Lumsden Michael D., Jakeman David L.: Glycosidase Inhibition by Macrolide Antibiotics Elucidated by STD-NMR Spectroscopy. CHEM BIOL 2008, 15, 739. <>
  • Bashan Anat, Yonath Ada: Correlating ribosome function with high-resolution structures. Trends Microbiol 2008, 16, 326. <>
  • Davidovich C., Bashan A., Yonath A.: Structural basis for cross-resistance to ribosomal PTC antibiotics. Proceedings of the National Academy of Sciences 2008, 105, 20665. <>