Development of homogeneous and heterogeneous asymmetric catalysts for practical enantioselective reactions

Ding, Kuiling

doi:10.1351/pac200678020293

Pure Appl. Chem., 2006, Vol. 78, No. 2, pp. 293-301

http://dx.doi.org/10.1351/pac200678020293

Development of homogeneous and heterogeneous asymmetric catalysts for practical enantioselective reactions

Kuiling Ding

State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China

Abstract: Two strategies for the development of practical asymmetric catalysis have been discussed in this article. The first part of this article focuses on the design and screening of highly efficient and enantioselective chiral catalysts for asymmetric hydrogenation reactions employing combinatorial approach. The second part presents a conceptually new strategy (i.e., "self-supporting" approach) for the immobilization of homogeneous catalysts through assembly of chiral multitopic ligands and metal ions without using any support. The success of this strategy will be exemplified in heterogeneous asymmetric carbonyl-ene, sulfoxidation, and epoxidation, as well as in asymmetric hydrogenation reactions.