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Pure Appl. Chem., 2006, Vol. 78, No. 2, pp. 231-239

Palladium-mediated cascade or multicomponent reactions: A new route to carbo- and heterocyclic compounds

Geneviève Balme, Didier Bouyssi and Nuno Monteiro

Laboratoire de Chimie Organique 1, CNRS UMR 5622, Université Claude Bernard, Lyon I, CPE. 43, Blvd. du 11 Novembre 1918, 69622 Villeurbanne, France

Abstract: In recent years, new processes based on transition-metal-mediated intramolecular addition reaction of heteronucleophiles and stabilized carbon nucleophiles to unactivated alkenes and alkynes have been developed in our laboratory. In this article, we summarize a number of recent synthetic applications of these new processes. Emphasis is placed on the development of multicomponent reactions based on a Pd-mediated intramolecular cyclization coupled with a carbon-carbon bond-forming reaction. Applications of this methodology to the synthesis of natural lignans are also reported.