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Pure Appl. Chem., 2004, Vol. 76, No. 9, pp. 1705-1714

New schemes for the synthesis of glycolipid oligosaccharide chains

N. E. Nifantiev, A. A. Sherman, O. N. Yudina, P. E. Cheshev, Y. E. Tsvetkov, E. A. Khatuntseva, A. V. Kornilov and A. S. Shashkov

N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, B-334 Moscow 119991, Russia

Abstract: The driving force for the constant improvement and development of synthetic methodologies in carbohydrate chemistry is the importance of natural oligosaccharide chains in numerous biological phenomena such as cell growth, differentiation, adhesion, etc. Here, we report our syntheses of the spacer-armed oligosaccharides of sialylated lacto- and neo- lacto-, globo-, ganglio-, and sulfoglucuronylparagloboside-series, which include new rationally designed synthetic blocks, efficient solutions for the stereoselective construction of glycosidic bonds, and novel protection group strategies.