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Pure Appl. Chem., 2004, Vol. 76, No. 5, pp. 965-972

Discovery of new anti-inflammatory agents

F. Fülöp, László Lázár, Z. Szakonyi, M. Pihlavisto, Sakari Alaranta, P. J. Vainio, Auni Juhakoski, Anne Marjamäki and D. J. Smith

Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies Corporation, Tykistökatu 6, FIN-20520 Turku, Finland

Abstract: We have synthesized a series of novel hydrazines and hydrazino alcohols that specifically inhibit vascular adhesion protein-1 (VAP-1), a human endothelial cell adhesion molecule with a well documented role in inflammation. VAP-1 is a semicarbazide-sensitive amine oxidase (SSAO), and the enzyme activity has been demonstrated to have a role in VAP-1 function. An indane hydrazino alcohol was able to reduce clinical symptoms of inflammation in experimental arthritis in rodents and has the potential to be a novel anti-inflammatory drug.