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Pure Appl. Chem., 2004, Vol. 76, No. 5, pp. 951-957

http://dx.doi.org/10.1351/pac200476050951

New endomorphin analogs with mu-agonist and delta-antagonist properties

G. Tóth, A. Keresztes, Cs. Tömböly, A. Péter, F. Fülöp, D. Tourwé, E. Navratilova, É. Varga, W. R. Roeske, H. I. Yamamura, M. Szucs and A. Borsodi

Institute of Biochemistry, Biological Research Center of Hungarian Academy of Sciences, Szeged, Hungary; University of Szeged, Hungary; Department of Organic Chemistry, Vrije University, Brussels, Belgium; University of Arizona Health Science Center, Tucson, AZ 85724, USA

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  • Mollica Adriano, Costante Roberto, Stefanucci Azzurra, Pinnen Francesco, Luisi Grazia, Pieretti Stefano, Borsodi Anna, Bojnik Engin, Benyhe Sándor: Hybrid peptides endomorphin-2/DAMGO: Design, synthesis and biological evaluation. European Journal of Medicinal Chemistry 2013, 68, 167. <http://dx.doi.org/10.1016/j.ejmech.2013.07.044>
  • Liu Wei X., Wang Rui: Endomorphins: potential roles and therapeutic indications in the development of opioid peptide analgesic drugs : ENDOMORPHINS: POTENTIAL ROLES AND THERAPEUTIC INDICATIONS. Medical Research Review 2012, 32, 536. <http://dx.doi.org/10.1002/med.20222>
  • Mallareddy Jayapal Reddy, Tóth Géza, Fazakas Csilla, Molnár Judit, Nagyőszi Péter, Lipkowski Andrzej W., Krizbai István A., Wilhelm Imola: Transport Characteristics of Endomorphin-2 Analogues in Brain Capillary Endothelial Cells : Transport of EM-2 Analogues Through the BBB. Chemical Biology and Drug Design 2012, 79, 507. <http://dx.doi.org/10.1111/j.1747-0285.2011.01306.x>
  • Keresztes Attila, Birkás Erika, Páhi Annamária, Tóth Géza, Bakota Lidia, Gulya Károly, Szücs Mária: Pharmacology of a new tritiated endomorphin-2 analog containing the proline mimetic cis-2-aminocyclohexanecarboxylic acid. Peptides (Fayetteville) 2011, 32, 722. <http://dx.doi.org/10.1016/j.peptides.2011.01.017>
  • Perlikowska Renata, Fichna Jakub, Wyrębska Anna, Poels Jeroen, Vanden Broeck Jozef, Toth Geza, Storr Martin, do Rego Jean-Claude, Janecka Anna: Design, Synthesis and Pharmacological Characterization of Endomorphin Analogues with Non-Cyclic Amino Acid Residues in Position 2. Basic Clin Pharmacol Toxicol 2010, 106, 106. <http://dx.doi.org/10.1111/j.1742-7843.2009.00476.x>
  • Perlikowska Renata, Gach Katarzyna, Fichna Jakub, Toth Geza, Walkowiak Bogdan, do-Rego Jean-Claude, Janecka Anna: Biological activity of endomorphin and [Dmt1]endomorphin analogs with six-membered proline surrogates in position 2. biorg med chem 2009, 17, 3789. <http://dx.doi.org/10.1016/j.bmc.2009.04.046>
  • Torino Domenica, Mollica Adriano, Pinnen Francesco, Lucente Gino, Feliciani Federica, Davis Peg, Lai Josephine, Ma Shou-Wu, Porreca Frank, Hruby Victor J.: Synthesis and evaluation of new endomorphin analogues modified at the Pro2 residue. Bioorganic & Medicinal Chemistry Letters 2009, 19, 4115. <http://dx.doi.org/10.1016/j.bmcl.2009.06.008>
  • Janecka Anna, Staniszewska Renata, Gach Katarzyna, Fichna Jakub: Enzymatic degradation of endomorphins. Peptides (Fayetteville) 2008, 29, 2066. <http://dx.doi.org/10.1016/j.peptides.2008.07.015>
  • You Lisha, Feng Song, An Rui, Wang Xinhong, Bai Donglu: Silica gel accelerated aza-Michael addition of amines to α,β-unsaturated amides. Tetrahetron Lett 2008, 49, 5147. <http://dx.doi.org/10.1016/j.tetlet.2008.06.099>
  • Staniszewska Renata, Fichna Jakub, Gach Katarzyna, Toth Geza, Poels Jeroen, Vanden Broeck Jozef, Janecka Anna: Synthesis and Biological Activity of Endomorphin-2 Analogs Incorporating Piperidine-2-, 3- or 4-Carboxylic Acids Instead of Proline in Position 2. Chem Biol Drug Design 2008, 72, 91. <http://dx.doi.org/10.1111/j.1747-0285.2008.00678.x>
  • Szemenyei Erzsébet, Tóth Géza: Tritium labelling and degradation studies of Dmt1-endomorphin 2. J Labelled Cpd Radiopharm 2007, 50, 1148. <http://dx.doi.org/10.1002/jlcr.1402>
  • Keresztes Attila, Tóth Géza, Fülöp Ferenc, Szűcs Mária: Synthesis, radiolabeling and receptor binding of [3H][(1S,2R)ACPC2]endomorphin-2. Peptides (Fayetteville) 2006, 27, 3315. <http://dx.doi.org/10.1016/j.peptides.2006.09.004>
  • Fülöp Ferenc, Forró Enikö, Tóth Gábor K.: A New Strategy To Produce β-Peptides:  Use of Alicyclic β-Lactams. Org Lett 2004, 6, 4239. <http://dx.doi.org/10.1021/ol048356t>