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Pure Appl. Chem., 2004, Vol. 76, No. 5, pp. 931-939

http://dx.doi.org/10.1351/pac200476050931

Search for noncompetitive 2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid receptor (AMPAR) antagonists: Synthesis, pharmacological properties, and computational studies

A. Chimirri, G. De Sarro, S. Quartarone, M. L. Barreca, R. Caruso, L. De Luca and R. Gitto

Dipartimento Farmaco-Chimico, Università di Messina, Viale Annunziata 98168, Messina, Italy; Dipartimento di Medicina Sperimentale e Clinica, Università di Catanzaro, Italy

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  • Russo Emilio, Gitto Rosaria, Citraro Rita, Chimirri Alba, De Sarro Giovambattista: New AMPA antagonists in epilepsy. Expert Opin. Investig. Drugs 2012, 21, 1371. <http://dx.doi.org/10.1517/13543784.2012.705277>
  • Budagumpi Srinivasa, Kulkarni Naveen V., Sathisha M. P., Netalkar Sandeep P., Revankar Vidyanand K., Suresh D. K.: Exploration on structure and anticonvulsant activity of transition metal complexes derived from an “end-off” compartmental bis-quinoxaline derivative with phthalazinyl-diazine as endogenous bridge. Monatshefte für Chemie 2011, 142, 487. <http://dx.doi.org/10.1007/s00706-011-0462-1>
  • Stancanelli Rosanna, Crupi Vincenza, De Luca Laura, Ficarra Paola, Ficarra Rita, Gitto Rosaria, Guardo Marta, Iraci Nunzio, Majolino Domenico, Tommasini Silvana: Improvement of water solubility of non-competitive AMPA receptor antagonists by complexation with β-cyclodextrin. biorg med chem 2008, 16, 8706. <http://dx.doi.org/10.1016/j.bmc.2008.07.085>
  • De Luca Laura, Gitto Rosaria, Barreca Maria Letizia, Caruso Roberta, Quartarone Silvana, Citraro Rita, De Sarro Giovambattista, Chimirri Alba: 3D Pharmacophore Models for 1,2,3,4-Tetrahydroisoquinoline Derivatives Acting as Anticonvulsant Agents. Arch Pharm Pharm Med Chem 2006, 339, 388. <http://dx.doi.org/10.1002/ardp.200600022>