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Pure Appl. Chem., 2003, Vol. 75, No. 2-3, pp. 235-249

Progress in fumagillin synthesis

W. Picoul, O. Bedel, A. Haudrechy and Y. Langlois

Laboratoire de Synthèse des Substances Naturelles,Associé au CNRS, Université de Paris-Sud, F-91405 Orsay, France

Abstract: After a brief account of the syntheses previously described in literature, several approaches of the antiangiogenic sesquiterpene fumagillin are described. Particularly, a Claisen–Ireland ring-closing metathesis strategy allowed the stereoselective preparation of several advanced intermediates in the fumagillin synthesis.