Pure Appl. Chem., 2002, Vol. 74, No. 8, pp. 1359-1368
http://dx.doi.org/10.1351/pac200274081359
Development of a practical synthesis of sumanirole
Abstract:
A new synthesis of sumanirole that is being developed to treat Parkinson's disease is described. The basic skeleton is constructed from 8-hydroxyquinoline and elaborated to the key tricylic intermediate 14. Further elaboration affords a 1,2-amino alcohol, which is converted to an aziridine by a new process. Finally, dissolving metal reduction to open the aziridine and protecting group removal affords sumanirole.