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Pure Appl. Chem., 2002, Vol. 74, No. 1, pp. 11-17

Functionalized main-group organometallics for organic synthesis

Paul Knochel, Eike Hupe, Wolfgang Dohle, David M. Lindsay, Véronique Bonnet, Guy Quéguiner, Andreas Boudier, Felix Kopp, Stéphane Demay, Naka Seidel, M. Isabel Calaza, Viet Anh Vu, Ioannis Sapountzis and Tanasri Bunlaksananusorn

Ludwig-Maximilians-Universität München, Department Chemie, Butenandtstrasse 5-13, Haus F, 81377 München, Germany

Abstract: Highly functionalized Grignard-reagents can be easily obtained by an iodine­magnesim exchange reaction and further reacted with various electrophiles. Via a B­Zn exchange reaction, a formal Michael addition with umpolung of the reactivity can be achieved. Chiral phosphine ligands can be easily synthesized by a 2.3 sigmatropic rearrangement and used successfully in asymmetric synthesis.