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Pure Appl. Chem., 2001, Vol. 73, No. 7, pp. 1189-1196

Synthesis of nucleoside analogs and new Tat protein inhibitors

A. Ané1, G. Prestat2, G. T. Manh1, M. Thiam3, S. Josse2, M. Pipelier2, J. Lebreton2, J. P. Pradère2 and D. Dubreuil2*

1 Laboratoire de Chimie Organique Structurale, Faculté des Sciences et des Techniques, 22 BP 582 Abidjan 22, Côte d'Ivoire
2 Laboratoire de Synthèse Organique, UMR au CNRS 6513, Faculté des Sciences et des Techniques, 2 rue de la Houssinière, BP 92208, 44322 Nantes 3, France
3 Laboratoire de Synthèse Organique, Faculté des Sciences et des Techniques, Université Cheikh Anta Diop, BP 5005 Dakar-Fann, Sénégal

Abstract: Two studies, concerning the synthesis of original nucleoside analogs regarded as an application of heterochemistry on thiaazaheterocycle systems from thiaazabutadienes are discussed. The preparation of new N- and C-nucleosides is presented. In the second part, the discovery of aromatic polycyclic derivatives as inhibitors of Tat protein is exposed. The work presented takes into account the participation of African partners in further synthetic research programs carried out in collaboration with the laboratory of Nantes.