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Pure Appl. Chem., 2001, Vol. 73, No. 7, pp. 1173-1188

From classical antimalarial drugs to new compounds based on the mechanism of action of artemisinin

Anne Robert, Françoise Benoit-Vical, Odile Dechy-Cabaret and Bernard Meunier

Laboratoire de Chimie de Coordination du CNRS, 205 Route de Narbonne, 31077 Toulouse Cedex 4, France

Abstract: A short review of the antimalarial drugs currently used in human clinics is reported. The molecular aspect of the different possible mechanisms of action of artemisinin is documented, including recent data on heme alkylation. The preparation and the in vitro antimalarial activity of new modular molecules named "trioxaquines" are also presented.