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Pure Appl. Chem., 2001, Vol. 73, No. 2, pp. 299-303

Recent advances in asymmetric catalysis. Synthetic applications to biologically active compounds

Jean Pierre Genet*, Angela Marinetti and Virginie Ratovelomanana-Vidal

E. N. S. C. P. , Laboratoire de Synthèse Sélective Organique et Produits Naturels, C. N. R. S. (UMR 7573) , 11 rue Pierre et Marie Curie, 75231 Paris Cedex 05, France

Abstract: New chiral cationic ruthenium complexes have been used for the industrial synthesis of (+) -dihydrojasmonate. A new class of electron-rich C2-symmetric 2,4-disubstituted phosphetanes (CnrPHOS) was developed. Preliminary evaluation of their catalytic properties revealed high efficiency in rhodium and ruthenium-catalyzed asymmetric hydrogenations. A new stereochemical model is presented in which the phosphetane Rh-catalyzed hydrogenation follows an apparent stability-controlled mechanism.