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Pure Appl. Chem., 2001, Vol. 73, No. 2, pp. 239-242

Some newer aspects of organozirconium chemistry of relevance to organic synthesis. Zr-Catalyzed enantioselective carbometallation

Ei-ichi Negishi

Herbert C. Brown Laboratories of Chemistry, Purdue University, West Lafayette, Indiana 47907-1393, USA

Abstract: The reaction of terminal alkenes with trialkylalanes in the presence of chiral (NMI) 2ZrCl2 has been shown to be 70-75% ee for methylalumination and 90-95% ee for ethyl- and higher alkylalumination. It must involve an acyclic bimetallic process. Its scope, limitations, and applications to some natural products syntheses are discussed.