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Pure Appl. Chem., 2000, Vol. 72, No. 9, pp. 1659-1670

Synthetic studies on the A83586C and bryostatin antitumor macrolides and the monamycin antibiotics

K. J. Hale, M. G. Hummersone, J. Cai, S. Manaviazar, G. S. Bhatia, J. A. Lennon, M. Frigerio, V. M. Delisser, A. Chumnongsaksarp, N. Jogiya and A. Lemaitre

The Christopher Ingold Laboratories, Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, UK

Abstract: After a brief summary of our asymmetric total syntheses of A83586C and 4-epi-A83586C, we will go on to describe some of our synthetic work on the monamycins, and our most recent total synthesis studies on the bryostatin antitumor macrolides.