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Pure Appl. Chem., 2000, Vol. 72, No. 9, pp. 1649-1653

http://dx.doi.org/10.1351/pac200072091649

Fluorous methods for synthesis and separation of organic molecules

Dennis P. Curran

Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260 USA

Abstract: Fluorous molecules partition out of an organic phase and into a fluorous (highly fluorinated) phase in a liquid-liquid extraction. New fluorous techniques allow simple yet substantive separations of organic reaction mixtures based on the presence or absence of a fluorous tag. Fluorous-tagged molecules can also be separated from nontagged molecules by solid phase extraction over fluorous reverse-phase silica gel. This technique is ideal for solution-phase parallel synthesis because it allows simple yet substantive separations of organic reaction mixtures.