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Pure Appl. Chem., 2013, Vol. 85, No. 6, pp. 1185-1202

Published online 2013-05-20

A hybrid approach to new molecular scaffolds

Kalanidhi Palanichamy and Krishna P. Kaliappan*

Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India

Abstract: Our various efforts toward the synthesis of a set of novel sugar hybrid scaffolds of several biologically active natural products such as taxol, steroids, β-lactams, and otteliones are presented. We have shown the application of the hybrid approach to design and rapidly generate a library of novel natural product-like compounds, which may have interesting biological features, using metathesis and/or cycloaddition reactions as key steps.