Pure Appl. Chem., 2013, Vol. 85, No. 6, pp. 1185-1202
http://dx.doi.org/10.1351/PAC-CON-13-02-08
Published online 2013-05-20
A hybrid approach to new molecular scaffolds
Abstract:
Our various efforts toward the synthesis of a set of novel sugar hybrid scaffolds of several biologically active natural products such as taxol, steroids, β-lactams, and otteliones are presented. We have shown the application of the hybrid approach to design and rapidly generate a library of novel natural product-like compounds, which may have interesting biological features, using metathesis and/or cycloaddition reactions as key steps.