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Pure Appl. Chem., 2013, Vol. 85, No. 2, pp. 377-384

Published online 2013-01-21

Transition-metal-catalyzed multicomponent coupling reactions with imines and carbon monoxide

Jeffrey S. Quesnel and Bruce A. Arndtsen*

Department of Chemistry, McGill University, 801 Sherbrooke Street W., Montreal, QC H3A2K6, Canada

Abstract: Multicomponent coupling reactions provide a method to combine several substrates in a single reaction. When coupled with transition-metal catalysis, these reactions can be used to both activate and control the assembly of multiple simple building blocks directly into useful products. This account will describe our work in this area, with a focus on the use of palladium catalysis as a tool to couple imines and CO with other substrates into a range of heterocyclic derivatives in one-step reactions.