Pure Appl. Chem., 2012, Vol. 84, No. 8, pp. 1749-1757
http://dx.doi.org/10.1351/PAC-CON-11-09-13
Published online 2012-03-29
Access to molecular complexity via gold- and platinum-catalyzed cascade reactions
Abstract:
We report recent progress on Au- and Pt-catalyzed cascade reactions to access complicated molecular frameworks. Reported reactions include new cyclization/cycloaddition cascades on carbonyl and epoxide substrates tethered with an allene, alkene, and alkyne. Such substrates enable Au-catalyzed cascade reactions comprising an initial cyclization to form reactive 1,n-dipole that undergoes subsequent cycloadditions with suitable dipolarophiles.
Keywords
alkynes; cascade reactions; catalysis; electrophilic activation; gold catalysis; molecular complexity; platinum catalysis; tandem reactions.