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Pure Appl. Chem., 2012, Vol. 84, No. 8, pp. 1749-1757

Published online 2012-03-29

Access to molecular complexity via gold- and platinum-catalyzed cascade reactions

Sabyasachi Bhunia and Rai-Shung Liu*

Department of Chemistry, National Tsing-Hua University, Hsinchu, Taiwan

Abstract: We report recent progress on Au- and Pt-catalyzed cascade reactions to access complicated molecular frameworks. Reported reactions include new cyclization/cycloaddition cascades on carbonyl and epoxide substrates tethered with an allene, alkene, and alkyne. Such substrates enable Au-catalyzed cascade reactions comprising an initial cyclization to form reactive 1,n-dipole that undergoes subsequent cycloadditions with suitable dipolarophiles.