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Pure Appl. Chem., 2012, Vol. 84, No. 7, pp. 1567-1574

Published online 2012-02-28

Spiroketals: Toward the synthesis of 39‑oxobistramide K

Malgorzata Commandeur, Claude Commandeur and Janine Cossy*

Laboratoire de Chimie Organique Associé au CNRS, ESPCI ParisTech, 10 rue Vauquelin, 75231 Paris Cedex 05, France

Abstract: An advanced spiroketal intermediate toward the synthesis of 39-oxobistramide K was prepared, fragment C14–C40. This fragment was obtained in 19 steps with an overall yield of 6.2 % using a FeCl3-catalyzed spiroketalization as the key step.