Chlorine-free copper-catalyzed oxidative synthesis of 1,3,4-oxadiazoles with molecular oxygen as the sole oxidant

Jiang, Huanfeng; Li, Xianwei; Pan, Xiaoyan; Zhou, Peng

doi:10.1351/PAC-CON-11-07-04

Pure Appl. Chem., 2012, Vol. 84, No. 3, pp. 553-559

http://dx.doi.org/10.1351/PAC-CON-11-07-04

Published online 2011-09-27

Chlorine-free copper-catalyzed oxidative synthesis of 1,3,4-oxadiazoles with molecular oxygen as the sole oxidant*

Huanfeng Jiang*, Xianwei Li, Xiaoyan Pan and Peng Zhou

School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China

Abstract: Chlorine-free is not only one of the new concepts of green chemistry, but also a problematical task for chemical processes in industrial utility. During the past several decades, we devoted ourselves to the study of chlorine-free organic synthesis. Herein, we describe an efficient chlorine-free copper-catalyzed oxidative approach providing 1,3,4-oxadiazoles in good yields from readily available starting materials. This transformation requires only a green and inexpensive reagent to afford the structurally useful motifs, and has a broad functional groups tolerance.

*Pure Appl. Chem. 84, 411–860 (2012). A collection of invited papers for the IUPAC project 2008-016-1-300 “Chlorine-free Synthesis for Green Chemistry”.