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Pure Appl. Chem., 2012, Vol. 84, No. 2, pp. 225-238

Published online 2012-01-16

A fully validated method for the determination of arsenic species in rice and infant cereal products

Toni Llorente-Mirandes1, Josep Calderón2, José Fermín López-Sánchez1, Francesc Centrich2 and Roser Rubio1*

1 Department of Analytical Chemistry, University of Barcelona, Martí i Franquès 1‑11, Barcelona E-08028, Spain
2 Laboratory of the Public Health Agency of Barcelona, Chemistry, Avda. Drassanes 13-15, 08001-Barcelona, Spain

Abstract: A full validation of inorganic arsenic (iAs), methylarsonic acid (MA), and dimethyl arsinic acid (DMA) in several types of rice and rice-based infant cereals is reported. The analytical method was developed and validated in two laboratories. The extraction of the As species was performed using nitric acid 0.2 % and hydrogen peroxide 1 %, and the coupled system liquid chromatography-inductively coupled plasma-mass spectrometry (LCICP-MS) was used for speciation measurements. Detection limit (DL), quantification limit, linearity, precision, trueness, accuracy, selectivity, as well as expanded uncertainty for iAs, MA, and DMA were established. The certified reference materials (CRMs) (NMIJ 7503a, NCS ZC73008, NIST SRM 1568a) were used to check the accuracy. The method was shown to be satisfactory in two proficiency tests (PTs). The broad applicability of the method is shown from the results of analysis of 29 samples including several types of rice, rice products, and infant cereal products. Total As ranged from 40.1 to 323.7 μg As kg–1. From the speciation results, iAs was predominant, and DMA was detected in some samples while MA was not detected in any sample.