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Pure Appl. Chem., 2012, Vol. 84, No. 11, pp. 2309-2315

Published online 2012-06-24

Isotope incorporation using organoboranes

George W. Kabalka*, Min-Liang Yao, Murthy Akula and Li Yong

Departments of Chemistry and Radiology, University of Tennessee, Knoxville, TN 37920, USA

Abstract: Isotopes have played an important role in chemistry, biology, and medicine. For the last three decades, we have focused on the use of organoboron compounds as precursors to isotopically labeled physiologically active reagents. During that period, we have successfully developed methods for incorporating short- and long-lived isotopes of carbon, nitrogen, oxygen, and the halogens using a variety of reactive organoboron precursors. In addition, labeling strategies employing polymer-supported organoboron derivatives were developed. In this report, we present a short overview focused on the evolution of radiolabeling techniques based on boron chemistry.