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Pure Appl. Chem., 2011, Vol. 83, No. 3, pp. 489-493

Published online 2011-01-18

Synthesis of mycalazol and mycalazal analogs with potent antiproliferating activities

Yasser M. A. Mohamed and Trond Vidar Hansen*

Department of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, P.O. BOX 1068, N-0316 Oslo, Norway

Abstract: Four 2,5-disubstituted pyrrole and two 2-disubstituted thiophene analogs of the natural products mycalazol 5 and mycalazal 2 have been prepared using the Stille coupling reaction. All four analogs displayed potent antiproliferating activity against several human cancer cell lines with IC50 values in the nanomolar range.