Pure Appl. Chem., 2011, Vol. 83, No. 3, pp. 489-493
http://dx.doi.org/10.1351/PAC-CON-10-09-27
Published online 2011-01-18
Synthesis of mycalazol and mycalazal analogs with potent antiproliferating activities
Abstract:
Four 2,5-disubstituted pyrrole and two 2-disubstituted thiophene analogs of the natural products mycalazol 5 and mycalazal 2 have been prepared using the Stille coupling reaction. All four analogs displayed potent antiproliferating activity against several human cancer cell lines with IC50 values in the nanomolar range.
Keywords
2,5-disubstituted pyrroles; antiproliferating activity; mycalazal 2; mycalazol 5; natural products; Stille coupling.