Pure Appl. Chem., 2011, Vol. 83, No. 3, pp. 425-433
http://dx.doi.org/10.1351/PAC-CON-10-09-12
Published online 2011-01-13
Synthetic studies toward the spiroimine unit of the spirolides
Abstract:
Synthetic studies toward the spiroimine unit of the spirolide family of shellfish biotoxins are described. Several strategies for introduction of the C7, C29, and C32 stereocenters of the A,E-ring system of the spirolides are described, such as spironitrone formation, Birch reductive alkylation, and asymmetric Diels–Alder cycloadditions.