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Pure Appl. Chem., 2010, Vol. 82, No. 8, pp. 1647-1662

http://dx.doi.org/10.1351/PAC-CON-09-09-24

Published online 2010-06-19

Concerning the ring-opening polymerization of lactide and cyclic esters by coordination metal catalysts

Malcolm H. Chisholm

Department of Chemistry, The Ohio State University, 100 W. 18th Ave., Columbus, OH 43210, USA

Abstract: A summary of the reactions involved in the ring-opening polymerization (ROP) of lactide (LA) to give polylactides (PLAs) is presented along with competing reactions. Particular attention is given to the stereoselective polymerization of rac-LA to give heterotactic PLA and meso-LA to give syndiotactic PLA by aluminum Schiff-based catalysts and to the development of highly active group 2 metal single-site catalysts. Melt or solvent-free polymerization is also described along with reactions that lead exclusively to cyclic-polylactides.