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Pure Appl. Chem., 2010, Vol. 82, No. 4, pp. 991-999

Published online 2010-03-20

Effect of molecular clips and tweezers on enzymatic reactions by binding coenzymes and basic amino acids

Frank-Gerrit Klärner1*, Thomas Schrader1, Jolanta Polkowska1, Frank Bastkowski1, Peter Talbiersky1, Mireia Campañá Kuchenbrandt1, Torsten Schaller1, Herbert de Groot2 and Michael Kirsch2

1 Institute for Organic Chemistry, University of Duisburg-Essen, Universitätsstrasse 7, 45117 Essen, Germany
2 Institute for Physiological Chemistry, Universitätsklinikum Essen, Hufelandstrasse 55, 45122 Essen, Germany

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  • Dutt Som, Wilch Constanze, Gersthagen Thomas, Wölper Christoph, Sowislok Andrea Anna, Klärner Frank-Gerrit, Schrader Thomas: Linker Effects on Amino Acid and Peptide Recognition by Molecular Tweezers. Eur. J. Org. Chem. 2013, 2013, 7705. <>
  • Klärner Frank-Gerrit, Schrader Thomas: Aromatic Interactions by Molecular Tweezers and Clips in Chemical and Biological Systems. Acc. Chem. Res. 2013, 46, 967. <>
  • Bier David, Rose Rolf, Bravo-Rodriguez Kenny, Bartel Maria, Ramirez-Anguita Juan Manuel, Dutt Som, Wilch Constanze, Klärner Frank-Gerrit, Sanchez-Garcia Elsa, Schrader Thomas, Ottmann Christian: Molecular tweezers modulate 14-3-3 protein–protein interactions. Nature Chem 2013, 5, 234. <>
  • Leblond Jeanne, Petitjean Anne: Molecular Tweezers: Concepts and Applications. Chem Eur J of Chem Phys 2011, 12, 1043. <>
  • Dutt Som, Wilch Constanze, Schrader Thomas: Artificial synthetic receptors as regulators of protein activity. Chem Commun 2011, 47, 5376. <>
  • Fotiadou Katerina, Thanassoulas Angelos, Nounesis George, Yannakopoulou Konstantina: Cooperative heterodimer formation between per-guadinylated and carboxylated or phosphorylated cyclodextrins in DMSO and DMSO–water studied by NMR spectroscopy and microcalorimetry. Supramolecular Chemistry 2011, 23, 493. <>
  • Schmidtchen Franz P.: Hosting anions. The energetic perspective. Chem Soc Rev 2010, 39, 3916. <>