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Pure Appl. Chem., 2010, Vol. 82, No. 1, pp. 243-257

Published online 2010-01-03

Structure-guided de novo design of α-helical antimicrobial peptide with enhanced specificity

Jin-Feng Huang1, Yi-Min Xu1, Dian-Ming Hao1, Yi-Bing Huang1, Yu Liu2* and Yuxin Chen1*

1 Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, Jilin University, Changchun, Jilin 130021, China
2 The Second Hospital, Jilin University, Changchun, Jilin 130041, China

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  • Zhao LianJing, Huang YiBing, Gao Song, Cui Yan, He Dan, Wang Li, Chen YuXin: Comparison on effect of hydrophobicity on the antibacterial and antifungal activities of α-helical antimicrobial peptides. Sci. China Chem. 2013, 56, 1307. <>
  • Huang Yi-Bing, He Li-Yan, Jiang Hong-Yu, Chen Yu-Xin: Role of Helicity on the Anticancer Mechanism of Action of Cationic-Helical Peptides. IJMS 2012, 13, 6849. <>
  • Huang Jinfeng, Hao Dianming, Chen Yu, Xu Yimin, Tan Juanjuan, Huang Yibing, Li Fan, Chen Yuxin: Inhibitory effects and mechanisms of physiological conditions on the activity of enantiomeric forms of an α-helical antibacterial peptide against bacteria. Peptides (Fayetteville) 2011, 32, 1488. <>