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Pure Appl. Chem., 2009, Vol. 81, No. 6, pp. 1027-1031

Published online 2009-05-05

Newly isolated marine Bacillus pumilus (SP21): A source of novel lipoamides and other antimicrobial agents

Fabrice Berrue, Abdelnasser Ibrahim, Patricia Boland and Russell G. Kerr*

Department of Chemistry and Department of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Prince Edward Island, C1A 4P3, Canada

Abstract: A screening of marine bacteria for antimicrobial activity resulted in the isolation of Bacillus pumilus (SP21) from a sediment sample collected in the Bahamas. A bioassay-guided fractionation led to the isolation of five surfactin analogs, glycocholic acid, amicoumacins A and B in addition to three new compounds named lipoamides A-C. The chemical structure of all the bioactive compounds was elucidated using spectroscopic methods including 2D NMR and MS. The antimicrobial activity of each compound was evaluated against a panel of pathogens and is reported herein.