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Pure Appl. Chem., 2009, Vol. 81, No. 2, pp. 181-194

Studies for the synthesis of marine natural products

David R. Williams, Martin J. Walsh, Christopher D. Claeboe and Nicolas Zorn

Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, IN 47405-7102, USA

Abstract: The process of allylic transposition in SE' reactions is a significant construct for synthesis. The flexibility of a variety of allylation strategies provides for the rational design of pathways to a diverse array of complex targets. Our recent studies of SE' reactions will examine issues of stereoselectivity and efficiency in the context of applications toward the synthesis of marine natural products such as the xenicane diterpenes, which feature the strained E-cyclononene ring system, and peloruside A, a 16-membered macrocyclic lactone.