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Pure Appl. Chem., 2009, Vol. 81, No. 2, pp. 169-180

http://dx.doi.org/10.1351/PAC-CON-08-09-17

Total synthesis of novel dictyostatin analogs and hybrids as microtubule-stabilizing anticancer agents

Ian Paterson, Nicola M. Gardner and Guy J. Naylor

University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, UK

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  • Paterson Ian, Naylor Guy J., Gardner Nicola M., Guzmán Esther, Wright Amy E.: Total Synthesis and Biological Evaluation of a Series of Macrocyclic Hybrids and Analogues of the Antimitotic Natural Products Dictyostatin, Discodermolide, and Taxol. Chem Asian J 2011, 6, 459. <http://dx.doi.org/10.1002/asia.201000541>
  • Ferreiro-Mederos Leticia, Vila-Gisbert Silvia, Urbano Antonio, Carreño M. Carmen, Colobert Françoise: Stereoselective synthesis of the C15–C26 fragment of the antitumor agent (−)-dictyostatin. Org Biomol Chem 2011, 9, 758. <http://dx.doi.org/10.1039/c0ob00491j>
  • Paterson Ian, Britton Robert, Delgado Oscar, Gardner Nicola M., Meyer Arndt, Naylor Guy J., Poullennec Karine G.: Total synthesis of (−)-dictyostatin, a microtubule-stabilising anticancer macrolide of marine sponge origin. Tetrahedron 2010, 66, 6534. <http://dx.doi.org/10.1016/j.tet.2010.01.083>
  • Zhu Wei, Jiménez María, Jung Won-Hyuk, Camarco Daniel P., Balachandran Raghavan, Vogt Andreas, Day Billy W., Curran Dennis P.: Streamlined Syntheses of (−)-Dictyostatin, 16-Desmethyl-25,26-dihydrodictyostatin, and 6-epi-16-Desmethyl-25,26-dihydrodictyostatin. J Am Chem Soc 2010, 132, 9175. <http://dx.doi.org/10.1021/ja103537u>