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Pure Appl. Chem., 2008, Vol. 80, No. 8, pp. 1683-1691

Chemoselective reactions: Toward the synthesis of biologically active natural products with anticancer activities

Sébastien Reymond, Laurent Ferrié, Amandine Guérinot, Patrice Capdevielle and Janine Cossy

Laboratoire de Chimie Organique ESPCI-Paris Tech, CNRS, 10 Rue Vauquelin, 75231 Paris Cedex 05, France

Abstract: Leucascandrolide A and migrastatin were synthesized efficiently by using chemoselective reactions such as olefin metatheses. The use of an iron-catalyzed cross-coupling reaction overcame difficulties encountered with palladium-catalyzed processes in our synthetic approach toward spirangien A.