Pure Appl. Chem., 2008, Vol. 80, No. 5, pp. 1055-1062
http://dx.doi.org/10.1351/pac200880051055
Cu(I)-catalyzed asymmetric allylation of ketones and ketimines
Abstract:
Chiral CuF-catalyzed asymmetric allylation of ketones and ketimines is described. Nucleophile activation via transmetallation (allylboronate to allylcopper), which is facilitated by a cocatalyst [La(OiPr)3 or LiOiPr], is key for these reactions. A CuOTf-3KOtBu-DUPHOS complex is a comparably effective catalyst that reduces the required amount of chiral phosphines.
Keywords
allylation; asymmetric catalysis; copper; ketimines; ketones; tetrasubstituted carbon.