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Pure Appl. Chem., 2008, Vol. 80, No. 5, pp. 1005-1012

http://dx.doi.org/10.1351/pac200880051005

New synthetic methodologies based on active transition metals

Francisco Alonso and Miguel Yus

Department of Organic Chemistry, Faculty of Science, and Institute of Organic Synthesis (ISO), University of Alicante, Apdo. 99, 03080 Alicante, Spain

Abstract: Active transition metals, namely, nickel, copper and iron, have been prepared by the reduction of the corresponding chlorides with lithium and a catalytic amount of an arene. These metals, in the form of nanoparticles, have found application in the reduction of a wide variety of functional groups as well as in the alkylation of methyl ketones with primary alcohols.