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Pure Appl. Chem., 2008, Vol. 80, No. 5, pp. 861-871

Ruthenium catalysts for selective nucleophilic allylic substitution

Christian Bruneau, Jean-Luc Renaud and Bernard Demerseman

UMR 6226, CNRS-Université de Rennes 1: Sciences Chimiques de Rennes, Catalyse et Organométalliques, Campus de Beaulieu-35042 Rennes Cedex, France

Abstract: Recent developments in the chemistry of η3-allylruthenium(IV) complexes are due to their straightforward synthesis resulting from oxidative addition of allylic substrates to a ruthenium(II) center. Subsequent reaction with a nucleophile is the basis of their involvement in the catalytic allylic substitution reaction. We focus here on ruthenium-catalyzed substitution of allylic substrates by C-, N-, and O-nucleophiles and show that selected ligands make regio- and enantioselective reactions possible.